The TUM spin-off IRUBIS offers continuous monitoring of bioreactors for the production of biopharmaceuticals.
Biopharmaceuticals are drugs which are produced by mammalian cells in so-called bioreactors. A major challenge is to ensure the optimal nutrient concentration (e.g. glucose) for these cells during the production process. This is why samples need to be taken and analyzed manually every day to adjust the supply.
To simplify and automize this costly process, IRUBIS developed Monipa. This device allows continuous monitoring and control of glucose, lactate and other parameters inside the bioreactor. Monipa is based on a well-established analytical method, mid-infrared spectroscopy, and includes a novel spectroscopy sensor and machine-learning software. Exchangeable single-use flow cells allow the monitoring of several bioreactors at the same time.